Heparin attenuates norepinephrine-induced venoconstriction
نویسندگان
چکیده
منابع مشابه
Effects of enalaprilat on venoconstriction to norepinephrine: role of prostaglandins.
OBJECTIVE Most patients with cardiovascular disease continue to receive both aspirin and an angiotensin-converting enzyme (ACE) inhibitor. This is despite the fact that ACE inhibition also inhibits the enzyme kininase II and leads to accumulation of bradykinin which increases prostaglandins. We hypothesized that in normal veins, vasodilator prostaglandins contribute significantly to ACE inhibit...
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Abstract Background and Objectives Heparin is still a commonly used anticoagulant in prophylaxis and treatment of thromboembolic events. Heparin-induced thrombocytopenia (HIT) is a life-threating adverse drug reaction of heparin. The diagnosis of HIT is made based on two important criteria, firstly clinical evaluation and secondly laboratory testing. In this comprehensive review, the authors w...
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Increased sympathetic nervous activity (SNA) elevates venomotor tone in deoxycorticosterone acetate (DOCA)-salt hypertension. We studied the mechanisms by which the SNA increases venomotor tone in DOCA-salt hypertension by making in situ intracellular recordings of venous smooth muscle cell (VSMC) membrane potential (E(m)) and measurement of outside diameter (OD) in mesenteric veins (MV) and me...
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The present investigation was designed to obtain additional evidence for the effect of carotid sinus reflexes on venous tone. It was found that occlusion of one or both common carotid arteries increases tension in a miniature balloon inserted into a peripheral vein. Deafferentation of the aortic arch by cervical vagotomy enhanced the venous response. The time course and magnitude of the venous ...
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V ENOCONSTRICTION has been suggested as an explanation for a variety of observations made on animals and humans suffering from cardiac decompensation.'-5 We have used the method described by Litter and coworkers for measuring peripheral venous distensibility' to study this aspect of congestive heart failure in man. The method measures the increment of limb volume occurring in response to a know...
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ژورنال
عنوان ژورنال: Vascular Medicine
سال: 1998
ISSN: 1358-863X,1477-0377
DOI: 10.1177/1358836x9800300202